李加敏，男，汉族，中共党员，1985年11月生，安徽宿州人，博士，博士后，讲师（青年副教授）。一直从事鱼类脂肪异常沉积的营养调控策略的研究，重点关注L-肉碱和甲基供体的降肝脂机制。以第一作者身份发表SCI收录论文5篇，参与发表14篇高水平科研论文。主持一项国家自然科学基金青年基金项目，参与多项国家级科研项目。
教育和工作经历：
2022.08-至今，太阳成集团tyc7111cc 太阳成集团tyc7111cc，讲师
2018.08-2022.06，中国海洋大学 农业农村部水产动物营养与饲料重点实验室，博士后，水产（海水鱼脂类营养代谢及调控方向），
2013.09-2018.06，华东师范大学，博士，动物学（水生动物营养代谢与调控方向），
2010.09-2013.06，重庆师范大学，硕士，动物学
2008.09-2010.06，北京联合大学，本科，生物技术
2005.09-2008.06，北京吉利大学，专科，生物技术及应用
代表性研究成果和学术奖励情况：
1. Li J.M., Zhang Z., Kong A.D., Lai W.C., Xu W.X., Cao X.F., Zhao M.X., Li J.B., Shentu J.K., Mai K.S., Ai Q.H.. Dietary L-carnitine regulates liver lipid metabolism via simultaneously activating fatty acid β-oxidation and suppressing endoplasmic reticulum stress in large yellow croaker fed with high-fat diets. British Journal of Nutrition, 1-12. doi:10.1017/S0007114522000101.
2.Li J.M., Xu W.X., Lai W.C.; Kong A.D., Zhang Z., Pang Y.N., Wang Z., Shentu J.K., Wu X.F., Mai K.S., Ai Q.H. Effect of dietary methionine on growth performance, lipid metabolism and antioxidant capacity of large yellow croaker (Larimichthys crocea) fed with high lipid diets. Aquaculture, 536(2021)736388.
3. Li J.M., Li L.Y., Zhang Y.X., Jiang Z.Y., Limbu S.M.,Qiao F., Degrace P., Chen L.Q., Zhang M.L., Du Z.Y. Functional differences between L- and D-carnitine in metabolic regulation evaluated using a low-carnitine Nile tilapia model. British Journal of Nutrition, 122(2019)625–638.
4. Li J.M., Li L.Y., Qin X., Degrace P., Demizieux L., Limbu S.M., Wang X., Zhang M.L., Li D.L., Du Z.Y. Inhibited carnitine synthesis causes systemic alteration of nutrient metabolism in zebrafish. Frontiers in Physiology, 9(2018)509.
5. Li J.M., Li L.Y., Qin X., Ning L.J., Lu D.L., Li D.L., Zhang M.L., Wang X. and Du Z.Y. Systemic regulation of L-carnitine in nutritional metabolism in zebrafish, Danio rerio. Scientific Reports, 7(2017) 40815.
6. 李加敏，朱嘉洁，杨崴，胡先成.河川沙塘鳢雌鱼性成熟过程中卵黄蛋白原含量变化.重庆师范大学学报. 30(2013): 17-21.
合作作者发表论文：
1. Dan Z.J., Jiang D.L., Zheng J.C., Tang Z.Y., Gong Y., Liu Y.T., Li J.M., Mai K.S., Ai Q.H.. Effects of dietary inorganic salts supplementation on growth performance, bone mineral deposition, intestinal morphology and immune response of turbot juveniles (Scophthalmus maximus L.) in fermented soybean meal-based diets. Aquaculture Nutrition 27(2021)2541-2554.
2. Li X.S., Chen Q.C., Li Q.F., Li J.M., Cui K., Zhang Y.Q., A.D., Zhang Y.J., Wan M., MaiK.S., Ai Q.H.. Effects of high levels of dietary linseed oil on the growth performance, antioxidant capacity, hepatic lipid metabolism, and expression of inflammatory genes in large yellow croaker (Larimichthys crocea). Frontiers in Physiology 12(2021)631850.
3. Pang Y.N., Xu X., Xiang X.J., Li Y.N., Zhao Z.Q., Li J.M., Gao S.N., Liu Q.D, Mai K.S., Qinghui Ai Q.H.. High fat activates O-GlcNAcylation and affects AMPK/ACC pathway to regulate lipid metabolism. Nutrients 13(2021)1740.
4. Lai W.C., Xu D., Li J.M., Wang Z., Ding Y., Wang X.N., Li X.S., Xu N., Mai K.S., Ai Q.H.. Dietary polystyrene nanoplastics exposure alters liver lipid metabolism and muscle nutritional quality in carnivorous marine fish large yellow croaker (Larimichthys crocea). Journal of Hazardous Materials 419(2021)126454.
5. Fang W., Chen Q.C., Li J.M., Liu Y.T., Zhao Z.Q., Shen Y.N., Mai K.S., Ai Q.H.. Endoplasmic reticulum stress disturbs lipid homeostasis and augments inflammation in the intestine and isolated intestinal cells of large yellow croaker (Larimichthys crocea). Frontiers in Immunology 12(2021)738143.
6. Li L.Y., Li J.M., Ning L.J., Lu D.L., Luo Y., Ma Q., Limbu S.M., Li D.L., Chen L.Q., Lodhi I., Degrace P., Zhang M.L., Du Z.Y.. Mitochondrial fatty acid β-oxidation inhibition promotes carbohydrate catabolism and protein deposition through energy homeostasis remodeling in fish. Journal of Nutrition 150(2020)2322–2335.
7. Li L.Y., Li J.M., Qiao F., Chen L.Q., Zhang M.L., Du Z.Y*. Inhibited carnitine synthesis impairs adaptation to high-fat diet in Nile tilapia (Oreochromis niloticus). Aquaculture Reports 16(2020)100249.
8. Sun SX, Hua XM, Deng YY, Zhang YN, Li JM, Wu Z, Lim SM, Lu DS, Yin HW, Wang GQ, Waagbø R, Livar F, Zhang ML, Du ZY*. (2018) Tracking pollutants in dietary fish oil: From ocean to table. Environmental Pollution 240:733-744
9. Ning L.J., He A.Y., Lu D.L., Li J.M., Qiao F., Li D.L., Zhang M.L., Chen L.Q. and Du Z.Y. Nutritional background changes hypolipidemic effects of fenofibrate in Nile tilapia (Oreochromis niloticus). Scientific Reports, 7(2017) 41706.
10. Pan H., Li L.Y., Li J.M., Wang W.L., Limbu S.M., Degrace P., Li D.L., Du Z.Y. Inhibited fatty acid b-oxidation impairs stress resistance ability in Nile tilapia (Oreochromis niloticus). Fish & Shellfish Immunology, 68 (2017) 500-508.
11. Ning L.J., He A.Y., Li J.M., Lu D.L., Li L.Y., Zhang M.L., Chen L.Q. and Du Z.Y. Mechanisms and metabolic regulation of PPARα activation in Nile tilapia (Oreochromis niloticus). Biochimica et Biophysica Acta-molecular and cell biology of lipids, 1861(2016) 1036-1048.
12. He A.Y., Ning L.J., Chen L.Q., Chen Y.L., Xing Q., Li J.M., Qiao F., Li D.L., Zhang M.L. and Du Z.Y. Systemic adaptation of lipid metabolism in response to low and high-fat diet in Nile tilapia (Oreochromis niloticus). Physiological Reports, 3 (2015) e12485.
13. He A.Y., Liu C.Z., Chen L.Q., Ning L.J., Qin J.G., Li J.M., Zhang M.L, and Du Z.Y. Molecular characterization, transcriptional activity and nutritional regulation of peroxisome proliferator activated receptor gamma in Nile tilapia (Oreochromis niloticus). General and Comparative Endocrinology, 223 (2015): 139-147.
14. 宁丽军, 李加敏, 孙胜香, 杜震宇. 鱼类脂肪酸β-氧化研究进展. 水产学报. 43(2019): 128-142.
主持或参加科研项目及人才计划项目情况：
主持课题1项：
1. 国家自然科学基金青年基金项目（31902379）- 心磷脂调控大黄鱼线粒体β-氧化的机制探究（2020.01-2022.12）
参与课题7项：
1. 国家海水鱼产业技术体系大黄鱼营养与饲料岗位（CARS-47-11）（2017.01-2020.12，2021.01-2022.12）
2. 国家重点研发计划-蓝色粮仓科技创新(2018YFD0900402)-水产动物糖和脂肪营养及调控研究(2018.12-2022.12)
3. 国家自然科学基金联合基金项目（U2106232）- 乙酰化修饰介导脂肪酸对海水鱼类脂代谢和炎性反应调控机制研究（2022.01-2025.12）
4. 国家自然科学基金重点项目（31830102）- 鱼类脂肪分解供能关键过程及其代谢调控机制研究（2019.01-2023.12）
5. 国家自然科学基金面上项目（31772859）- 低肉碱罗非鱼模型的建立及其能量内稳态调控机制研究（2018.01-2021.12）
6. 国家自然科学基金青年基金项目（31502179）- IGF-1高表达转基因鲫鱼分解代谢失衡的分子机制研究（2016.01-2018.12）
7. 国家自然科学基金面上项目（31472290）- 线粒体和过氧化物酶体在鱼类脂肪酸β-氧化中的协作机制研究（2015.01-2018.12）
